Hyperacute extensive spinal cord infarction and negative spine magnetic resonance imaging: a case report and review of the literature

Rationale: Spinal cord infarction (SCI) accounted for only 1% to 2% of all ischemic strokes and 5% to 8% of acute myelopathies. Magnetic resonance imaging (MRI) play a role in the exclusion of non-ischemic etiology, but the diagnostic accuracy of this procedure may be low in confirming the diagnosis, even when the vast marrow lesions are present. Indeed, changes in MRI T2 can develop from hours to days, thus accounting for the low sensitivity in the setting of hyperacute (ie, within 6 hours of onset of symptoms).

For this reason, SCI remains a clinical diagnosis. Although the diagnostic work-up wide, up to 20% to 40% of cases of SCI are classified as cryptogenic. Here, we describe a case of cryptogenic longitudinally extensive transverse myelopathy due to SCI, with negative MRI and diffusion-weighted imaging at 9 hours after the initial symptoms.

patient concerns: A 51 years old woman presented to our emergency department with severe acute abdominal pain, nausea, vomiting, sudden-onset bilateral leg weakness with diffuse sensory loss and paraesthesia in the trunk and legs.
Diagnosis: On neurological examination, she showed severe paraparesis and sensory level D6. A spinal cord 3T MRI with gadolinium performed at 9 hours after onset of symptoms does not detect changes in the spinal cord. Due to the persistence of a suggestive clinical picture of myelopathy acute, 3T MRI of the spine was repeated after 72 hours showed hyperintense “pencil-like” signals mainly involving the gray matter of T1 to T6 at T2 sequence, slightly hypointense on T1 and the diffusion limited.

Intervention: Patients were given a salicylic acid (100 mg / d), a low molecular weight heparin prophylaxis, and start neuromotor rehabilitation.
Results: Two months later, a follow-up neurological examination revealed severe spastic paraparesis, there is a clear sensory level and sphincter control was poor with bladder distension.

Lesson: Apart from a relatively low frequency in the general population, SCI should be suspected in any patient presenting with symptoms of acute and progressive myelopathic, even without the presence of vascular risk factors. Thus, the clinical presentation consistent with a potential vascular syndromes involving the spinal cord MRI override initially negative and should not delay the timely and proper management.

Cultivated tomato (Solanum lycopersicum L.) suffer severe bottlenecks during domestication of the strain: Implications of the chloroplast genome

In a variety of plants, genetic bottlenecks occur through domestication can limit plant resistance to biotic and abiotic stresses. In this study, we investigated the nucleotide diversity in tomato chloroplast genome by sequencing seven plastomes of cultivated accessions from the Campania region (southern Italy) and two wild species among the closest (Solanum pimpinellifolium) and most distantly related (S. neorickii) tomato species cultivated. comparative analysis between the chloroplast genome sequenced in this work and are available at GenBank allowed to evaluate the variability plastomes and defining phylogenetic relationships.

A dramatic reduction in genetic diversity detected in cultivated tomatoes, however, de novo mutations some, still distinguishable tomatoes cultivated from the nearest wild relative S. pimpinellifolium, which are detected and can potentially be used as a diagnostic marker. phylogenetic analysis confirms that S. pimpinellifolium is the closest ancestor of all cultivated tomatoes. Local accession all gathered together and strictly related to other cultivated tomato (S. lycopersicum group). Noteworthy, S. lycopersicum var. cerasiforme resulting in a mix of both cultivated and wild tomato genotypes for one of the two accessions analyzed teem with tomatoes cultivated, whereas others with S. pimpinellifolium.

 Hyperacute extensive spinal cord infarction and negative spine magnetic resonance imaging: a case report and review of the literature
Hyperacute extensive spinal cord infarction and negative spine magnetic resonance imaging: a case report and review of the literature

The whole exome Analysis of Congenital Muscular Dystrophy and congenital myopathy patients from India Unveils Wide Spectrum of Known and Novel Mutation

Background: Congenital muscular dystrophy (CMD) and the congenital myopathies (CM) is a clinically heterogeneous group of genetic and degenerative primary muscle disorder with onset at birth or during infancy. Due to the extensive heterogeneity, clinical examination and analysis of protein-based often fail to identify the genetic causes of this disease.

Methods: Whole exome sequencing (WES) conducted to identify genetic mutations and diagnose pathogens cohort of 36 hard-to-diagnose cases CM CMD and Indian origin, using a variant of the call and a rigorous filtration process variants. Furthermore, in silico modeling and molecular dynamics (MD) study conducted for a number of novels and missense variants.

Results: A total of 33 and 21 rare and damaging mutations identified in 28 genes were previously reported in CMD and CM based OMIM, ClinVar and Orphanet, respectively. We can accurately diagnose 54% of patients (n = 12/22) in the group of CMD and 35% of patients (n = 5/14) in the group CM. Furthermore, the study for the MD is located in LMNA mutations, lama2 and RYR1, indicating that the wild type of protein is more stable than their mutant counterparts, implying a potential mechanism of pathogenesis.

NATtrol Influenza A H1, External Run Control, Medium (6 X 1 mL)

NATFLUAH1-ERCM 6 X 1 mL
EUR 401.52
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol Influenza A H1N1, External Run Control, Medium (6 X 1 mL)

NATFLUAH1N1-ERCM 6 X 1 mL
EUR 401.52
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol Clostridium difficile NAP1, External Run Control, Low (6 X 1 mL)

NATCDI(NAP1)-ERCL 6 X 1 mL
EUR 401.52
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NATtrol Cytomegalovirus (CMV) Strain: AD-169 External Run Control, Low (6X1 mL)

NATCMV-ERCL 6X1 mL
EUR 339.12
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NATtrol Mycoplasma pneumoniae M129, External Run Control, Low (6 X 1 mL)

NATMPN(M129)-ERCL 6 X 1 mL
EUR 339.12
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NATtrol Neisseria gonorrhoeae Z017, External Run Control, Low (6 X 1 mL)

NATNG-ERCL 6 X 1 mL
EUR 339.12
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol Staphylococcus aureus (MRSA) External Run Control, Low (6 X 1 mL)

NATSAU(MRSA)-ERCL 6 X 1 mL
EUR 339.12
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol Zika Virus (PRVABC59), External Run Control, Low (6 x 1.0 mL)

NATZIKV(PRV)-ERCL 6 x 1.0 mL
EUR 330.8
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NATtrol Mycoplasma genitalium External Run Control (6 x 0.25mL)

NATMGN-ERC 6 x 0.25mL
EUR 291.28
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NATtrol Chlamydia trachomatis serotype D, External Run Control, Low (6 X 1 mL)

NATCT(D-UW3)-ERCL 6 X 1 mL
EUR 339.12
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NATtrol Epstein Barr Virus (EBV) Strain: B95-8, External Run Control-Low (6X1mL)

NATEBV-ERCL 6X1mL
EUR 329.76
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol Cytomegalovirus (CMV) Strain:AD-169 External Run Control, Medium (6X1mL)

NATCMV-ERCM 6X1mL
EUR 401.52
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol Chlamydia trachomatis serotype D, External Run Control, Medium (6X1mL)

NATCT(D-UW3)-ERCM 6X1mL
EUR 401.52
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NATtrol P. jirovecii Recombinant External Run Control (6 x 0.5mL)

NATPJI-ERC 6 x 0.5mL
EUR 343.28
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NATtrol Staphylococcus aureus (MSSA); -mecA,External Run Control, Medium (6X1mL)

NATSAU(MSSA)-ERCM 6X1mL
EUR 401.52
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NATtrol Chlamydia trachomatis LGV II 434, External Run Control, Low (6 X 1 mL)

NATCT(434)-ERCL 6 X 1 mL
EUR 339.12
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NATtrol Escherichia coli 0157:H7;EDL933, External Run Control, Low (6 X 1 mL)

NATECO(933)-ERCL 6 X 1 mL
EUR 339.12
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NATtrol HIV Type 1 Strain: IIIB External Run Control, Low (6 X 1 mL)

NATHIV1-ERCL 6 X 1 mL
EUR 339.12
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Rat IgG-Biotin conjugate (isotype control) (Isotype control)

20005-B 100 ug
EUR 164

Low control Human Serum

35-S4321H000-L4 10 ml
EUR 116
Description: Low control human Serum

NATtrol BK Virus External Run Control, Medium (6 X 1 mL)

NATBK-ERCM 6 X 1 mL
EUR 401.52
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol Chlamydia trachomatis LGV II 434, External Run Control, Medium (6X1mL)

NATCT(434)-ERCM 6X1mL
EUR 401.52
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NATtrol CT/NG External Run Control, Negative (6 X 1 mL)

NATCT/NGNEG-6MC 6 X 1 mL
EUR 226.8
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NATtrol Zika Virus (PRVABC59), External Run Control, Medium (6 x 1.0mL)

NATZIKV(PRV)-ERCM 6 x 1.0mL
EUR 391.12
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NATtrol Zika Virus, External Run Control, Medium (6 x 1 mL)

NATZIKV-ERCM 6 x 1 mL
EUR 391.12
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Goat IgG (-ve control for flow cytometry) (isotype control)

20011-100 100 test
EUR 103

NATtrol Influenza A/B Positive Control (6 X 0.5 mL)

NATFLUA/B-6MC 6 X 0.5 mL
EUR 232
Description: Please contact Gentaur in order to receive the datasheet of the product.

Human Apolipoprotein B protein control for WB

APOB21-C 100 ul
EUR 286

BSA Control for Age-BSA

2221-BSA
EUR 175

BSA Control for AGE-BSA

35R-AA007 10 mg
EUR 224
Description: BSA Control for AGE protein (BSA modified), Cat No. 30R-AA007

NATtrol Clostridium difficile NAP1, External Run Control, Medium (6 X 1 mL)

NATCDI(NAP1)-ERCM 6 X 1 mL
EUR 499.28
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol Epstein Barr Virus (EBV) Strain:B95-8,External Run Control-Medium(6X1mL)

NATEBV-ERCM 6X1mL
EUR 391.12
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol Mycoplasma pneumoniae M129, External Run Control, Medium (6 X 1 mL)

NATMPN(M129)-ERCM 6 X 1 mL
EUR 401.52
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol Neisseria gonorrhoeae Z017, External Run Control, Medium (6 X 1 mL)

NATNG-ERCM 6 X 1 mL
EUR 401.52
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol Staphylococcus aureus (MRSA) External Run Control, Medium (6 X 1 mL)

NATSAU(MRSA)-ERCM 6 X 1 mL
EUR 401.52
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Core Panel Multi-Tumor control slides

TS900 Set of 5
EUR 218

Core Panel Multi-Tumor control slides

TS900-25 Set of 25
EUR 485

Breast Panel Multi-Tumor control slides

TS901 Set of 5
EUR 218

Breast Panel Multi-Tumor control slides

TS901-25 Set of 25
EUR 485

Control siRNA Vector (pGB-control)

9500C-20
EUR 338

Ferret IgG (Control, non-immune, isotype control), semi-pure for ELISA

20021-1 100 ug
EUR 225

Elk IgG, semi-pure for ELISA (Control, non-immune, isotype control)

20024-1 100 ug
EUR 225

Deer IgG, semi-pure for ELISA (Control, non-immune, isotype control)

20024-2 100 ug
EUR 225

Bison IgG, semi-pure for ELISA (Control, non-immune, isotype control)

20025-1 100 ug
EUR 225

Raccoon IgG, semi-pure for ELISA (Control, non-immune, isotype control)

20026-1 100 ug
EUR 225

Skunk IgG, semi-pure for ELISA (Control, non-immune, isotype control)

20027-1 100 ug
EUR 225

Control for HER2, 4 cases (1.5mm)

HRC081 1
EUR 85
Description: IHC control array containing 4 breast cancer cases of strong, moderate, low and negative HER2 breast cancer expressers in duplicates

Control for PR, 3 cases (1.5mm)

PRC061 1
EUR 85
Description: IHC control array containing 3 breast cancer cases of strong, moderate, low/negative progesterone receptor (PR) expressers in duplicates

SLLK, Control Peptide for TSP1 Inhibitor

HY-P0301 1mg
EUR 133

Control for ER, 4 cases (1.5mm)

ERC081 1
EUR 85
Description: IHC control array containing 4 breast cancer cases of strong, moderate, weak/nil estrogen receptor (ER) expressers in duplicates

Control for DOG1, 3 cases (1.5mm)

DOG1061 1
EUR 85
Description: IHC control array containing 3 GIST cases of strong, moderate, weak/nil DOG1 expressers in duplicates

Control for Ckit, 6 samples (1.5mm)

CKIT061 1
EUR 85
Description: Gastrointestinal stroma tumors, 6 cores, 3 cases in duplicates showing strong, moderate and no expression of cKit molecule.

PAS/Glycogen, For Digestion (Control Slides)

TCS0024-100 100 Slides
EUR 706

PAS/Glycogen, For Digestion (Control Slides)

TCS0024-25 25 Slides
EUR 232

PAS/Glycogen, For Digestion (Control Slides)

TCS0024-5 5 Slides
EUR 98

Thiostatin Rat protein, control for western

TSTN11-C 100 ul
EUR 286

Control/Blocking peptide for Human WNT5a

WNT511-P 100 ug
EUR 164

Human Liver Cathepsin B protein control for Western blot

CTHB11-C 100 ul
EUR 286

Quality Control

abx098966-1vial 1 vial
EUR 300

pMD18- Control

PVT10563 2 ug
EUR 266

pMD19- Control

PVT10564 2 ug
EUR 266

NATtrol Influenza A/B Positive Control (6 x 0.5mL)

NATFLUAB-6C 6 x 0.5mL
EUR 226.8
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol Escherichia coli 0157:H7;EDL933, External Run Control, Medium (6 X 1 mL)

NATECO(933)-ERCM 6 X 1 mL
EUR 401.52
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol HIV Type 1 Strain: IIIB External Run Control, Medium (6 X 1 mL)

NATHIV1-ERCM 6 X 1 mL
EUR 401.52
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Rat IgG2a Isotype Control LOW ENDOTOXIN

12-168-C100 0.1 mg
EUR 136

Rat IgG2b Isotype Control LOW ENDOTOXIN

12-169-C100 0.1 mg
EUR 136

Purified Influenza A Neuraminidase (H1N1-NA) protein control for western blot

H1N1NA11-C 100 ul
EUR 286

Donkey IgG (Control, non-immune, isotype control)

20028-1 1 mg
EUR 164

Rat neurofascin (Nfasc)-control Control/blocking peptide

AB-23249-CP 100ug
EUR 164

Control Sections for FD NeuroSilver™ Kit

PCS101 each
EUR 58

Positive Control for Anti-Rat MEH Antibody

MEHCON 100 uL
EUR 125

Positive Control for Anti-Human CYP1A2 Antibody

P1A2CON 100 uL
EUR 125

Positive Control for Anti-Rat CYP2B1 Antibody

P2B1PTCON 100 uL
EUR 125

Positive Control for Anti-Rat CYP2C Antibody

P2CCON 100 uL
EUR 125

Positive Control for Anti-Rat CYP2D Antibody

P2DCON 100 uL
EUR 125

Positive Control for Anti-Human CYP2E1 Antibody

P2E1PTCON 100 uL
EUR 125

Positive Control for Anti-Rat CYP3A2 Antibody

P3A2PTCON 100 uL
EUR 125

Positive Control for Anti-Human CYP3A Antibody

P3ACON 100 uL
EUR 125

Positive Control for Anti-Human CYP1B1 Antibody

PH1B1CON 100 uL
EUR 125

SLLK, Control Peptide for TSP1 Inhibitor(TFA)

HY-P0301A 5mg
EUR 380

Mouse IgG (-ve control for flow cytometry)

20008-1-100 100 tests
EUR 103

Rabbit IgG (-ve control for flow cytometry)

20009-1-100 100 tests
EUR 103

Purified Flagellin (salmonella) protein control for WB

FLGN17-C 100 ul
EUR 286

Purified, Bovine S100 protein control for WB

S1001-C 100 ul
EUR 286

Purified, Human S100 protein control for WB

S1002-C 100 ul
EUR 286

Control/Blocking peptide for Mouse Vimentin (Vim)

VIM11-C 100 ug
EUR 164

Control/Blocking peptide for Human WNT-1

WNT111-P 100 ug
EUR 457

Chicken Egg Ovalbumin protein control for Western

OVA11-C 100 ul
EUR 286

Mouse negative control sera (purified) for IHC

NCM802M 7 ml
EUR 199

Control/Blocking peptide for Ephrin-B2 antibody

NIVE2B-C 100 ug
EUR 164

Purified bovine Lactoferrin protein control for Western

LTF13-C 100 ul
EUR 286

Haptoglobin Human Plasma protein control for WB

HGLB18-C 100 ul
EUR 286

Conclusions: The findings WES has led us to identify new variants were reported as well as for the first time in India CMD and CM patients. This allows us to achieve an accurate genetic diagnosis that are otherwise difficult using conventional diagnostic tools. Transferring WES findings for clinical practice will help the clinical care of patients affected guided and informed genetic counseling.

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